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陈柯源

陈柯源,讲师,主要研究方向包括益生菌调节病原菌感染宿主的机制研究,人兽共患病分子流行病学研究,陆生野生动物救护与疫病防控。

  • 通讯地址

    浙江省杭州市临安区武肃街666号学2-308

    邮箱:chenky@zafu.edu.cn



  • 教育背景

    博士(2020/09-2024/06): 中国农业大学,临床兽医学专业

    硕士(2017/09-2020/06): 中国农业科学院,兽医专业

    学士(2013/09-2017/06): 河南农业大学,动植物检疫(动物检疫)专业

  • 工作经历

    2024/07 - 至今:浙江农林大学动物科技学院·动物医学院 讲师

  • 获奖荣誉

    1. 中国农业大学“优秀毕业生”

    2. 中国农业大学“三好学生”

    3. 香港崇正奖学金

    4. 中国农业大学“一等学业奖学金”

    5. 中国农业大学动物医学院博士生学术论坛墙报优秀奖

    6. 中国畜牧兽医学会兽医产科学分会论文优秀奖并作大会汇报

    7. 中国农业大学“二等学业奖学金”

    8. 中国农业科学院研究生院课程学习优秀奖

    9. 大北农励志奖学金

  • 研究方向

    1. 益生菌调节病原菌感染宿主的机制研究

    2. 人兽共患病分子流行病学研究

    3. 陆生野生动物救护与疫病防控

  • 发表论文

    SCI收录

    2024

    1. Yang Zhen#, Chen Keyuan#, Liu Yu, Wang Xuehong, Wang Shengyi, and Hao Baocheng. Regulation and analysis of Simiao Yong’an Decoction fermentation by Bacillus subtilis on the diversity of intestinal microbiota in Sprague-Dawley rats[J]. Veterinary Word. 2024, 17(3):712-719.

    2. Wei Li, Xue Wang, Keyuan Chen, Yaohong Zhu, Guiyan Yang, Yipeng Jin, Jiufeng Wang. Engineered Bacillus Subtilis WB600/ZD prevents Salmonella Infantis-induced intestinal inflammation and alters colon microbiota in a mouse model. Veterinary Research. 2024. (Accepted)

    3. Chen Keyuan, Wang Jing, Hu Ting, ZhaoYiqing, Wu Yi, Wang Xue, Li Wei, Yang Guiyan, Zhang Linlin, Wang Jiufeng, Zhu Yaohong. Salmonella enterica serovar Typhimurium effectors spiA and spiC promote replication by modulating iron metabolism and oxidative stress[J]. Veterinary Microbiology. 2024.

    4. Hu Ting, Song Zhiguan, Yang Lan, Chen Keyuan, Wu Yi, Xie Fei, Wang Jiufeng, Yang Guiyan, Zhu Yaohong. Maternal probiotic mixture supplementation optimizes the gut microbiota structure of offspring piglets through the gut-breast axis[J]. Animal Nutrition, 2024.

    2023

    1. Chen Keyuan, Wang Jiufeng, Guo Liang, Wang Jing, Yang Lan, Hu Ting, Zhao Yiqing, Wang Xue, Zhu Yaohong. Lactobacillus johnsonii L531 Ameliorates Salmonella enterica Serovar Typhimurium diarrhea by modulating iron homeostasis and oxidative stress via the IRP2 pathway[J]. Nutrients. 2023, 15(5): 1127.

    2. Wang Jing, Chen Keyuan, Wang Shenghua, Liu Yi, Zhao Yiqing, Yang Lan, Yang Guanghui, Wang Xiaojia, Zhu Yaohong, Yin Jinhua, Wang Jiufeng. Effects of spatial expression of ATF4 on the pathogenicity of different phenotypes of bovine viral diarrhea virus by regulating endoplasmic reticulum-mediated autophagy process[J]. Microbiology Spectrum,2023: e422522.

    3. Wang Jing, Yin Jinhua, Wang Shenghua, Chen Keyuan, Wang Jiufeng. Development and application of an indirect ELISA based on recombinant E2 protein for serological detection of bovine viral diarrhea virus infection in cattle[J]. Molecular Biology Reports, 2023.

    4. Zhang Linlin, Yang Guanghui, Wang Jun, Zhang Jialu, Chen Keyuan, Xiong Xiaoran, Zhu Yaohong, Xu Chuang, Wang Jiufeng. Ethyl Gallate inhibits Bovine Viral Diarrhea Virus by promoting IFITM3 expression, lysosomal acidification and protease activity[J]. Int J Mol Sci. 2023, 24(10): 8637.

    2021

    1. Cheng Feng#, Mo Yanan#, Chen Keyuan, Shang Xiaofei, Yang Zhen, Hao Baocheng, Shang Ruofeng, Liang Jianping, Liu Yu. Integration of metabolomics and transcriptomics indicates changes in MRSA exposed to terpinen-4-ol[J]. BMC Microbiol. 2021, 21(1): 305.

    2020

    1. Chen Keyuan, Gao Yan, Wang Xinjian, Cheng Feng, Ul Haq Shahbaz, Liang Yun, Yang Zhiwei, Li Bo, Liu Yuan, Wang Yonggang, Liang Jianping and Hao Baocheng. Regulation and analysis of the diversity of intestinal microbiota in SD rats by Danggui Buxue Tang (DBT) fermented with Bacillus subtilis[J]. Annals of Microbiology. 2020, 70: 31.


    中文期刊

    2020

    1. 陈柯源,宋向东,程峰,等.当归补血汤发酵产物对肉鸡免疫和抗氧化能力的影响[J].江苏农业学报. 2020, 36(04): 992-999.

    2019

    1. 陈柯源, 郝宝成, 丁自强, 梁剑平. 响应面法优化当归补血汤液体发酵工艺[J]. 中国畜牧兽医. 2019, 46(10): 2946-2954.

    2. 陈柯源, 高艳, 郝宝成, 梁剑平. 益生菌发酵中药研究进展[J]. 动物医学进展. 2019, 40(12): 74-78.