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李园

博士/副教授

女,副教授,入选2025-2027年度浙江省科协青年人才托举培养项目、入选浙江农林大学天目青年学者计划。主要从事单细胞抗体的制备、中和抗体特异性疗法及纳米佐剂创制相关的研究,聚焦重大动物疫病防控,开发新型动物免疫制剂,致力于养殖业的绿色健康发展。指导本科生获得国家级奖项3项,省级奖项5项,获第十五届浙江省大学生职业规划大赛优秀指导教师、浙江省高等学校青年教师助讲培养考核优秀、浙江农林大学“求真杯”教师教学创新大赛三等奖、浙江农林大学动物科技学院·动物医学院2024“最美动科动医人”等荣誉。主持国家自然科学基金、浙江省自然科学基金、国家博士后面上项目等项目,参与十三五国家重点研发计划专项、国家自然科学基金面上项目、浙江省自然科学基金重点项目等多个项目,申请国家发明专利10余项;在J Virol,Virulence,J Hazard Mater,ACS Appl Mater Interfaces等期刊发表论文20余篇,其中封面3篇,年度热点文章1篇,担任J Agri Food Chem, Anal Chem等SCI期刊审稿人,担任Animal and Zoonoses青年编辑以及教育部学位论文通讯评议专家。

  • 通讯地址

    浙江省杭州市临安区武肃街666号学2-302-1

    邮编:311300

    E-mail:Liyuan@zafu.edu.cn\18234475242@163.com

  • 教育背景

    2018.09-2022.07 中国农业大学 兽医专业 博士


    2015.09-2018.07 山西农业大学 生物化学与分子生物学专业 硕士


    2011.09-2015.07 山西农业大学 生物科学专业 学士

  • 工作经历

    2022/07 – 2023/05:浙江农林大学动物科技学院·动物医学院 讲师

    2023/04-2025/04:浙江大学 动物科学学院/浙江惠嘉生物有限公司 博士后

    2023/05 –至今:浙江农林大学动物科技学院·动物医学院 副教授

  • 学术兼职

    1. Animal and Zoonoses青年编辑,

    2.担任J Agri Food Chem, Anal Chem等SCI期刊审稿人

    3.教育部学位论文通讯评议专家

  • 课程教学

    承担研究生课程《动物源性食品安全》,本科生课程《生物信息学》

  • 获奖荣誉

    [个人荣誉与奖励]

    8.2024.12第十五届浙江省大学生职业规划大赛优秀指导教师

    7.2024.12浙江农林大学第六届研究生优秀导学团队

    6.2024.12浙江农林大学“求真杯”教师教学创新大赛校级 三等奖

    5.2024.10浙江农林大学动物科技学院·动物医学院教学创新大赛2024二等奖

    4.2024.06浙江农林大学动物科技学院·动物医学院2024“最美动科动医人”

    3.2024.01浙江农林大学动物科技学院·动物医学院科研工作先进个人

    2.2023.12浙江农林大学动物科技学院·动物医学院年度综合考核优秀

    1. 2023.05浙江省高等学校青年教师助讲培养考核优秀

    [指导学生(第一指导老师)]

    10.2025浙江省第十九届“挑战杯”大学生课外学术科技作品竞赛 银奖

    9.2025“东湖杯”大学生课外学术科技作品竞赛 特等奖

    8.2025第十届全国大学生生命科学竞赛 三等奖

    7.2025浙江省第十七届大学生生命科学竞赛 二等奖

    6.2024第九届全国大学生生命科学竞赛 三等奖

    5.2024浙江省国际大学生创新创业大赛(2024)银奖

    4.2024浙江省第十六届大学生生命科学竞赛 二等奖

    3.浙江农林大学2024大学生创新大赛 银奖

    2.第五届“卓越杯”文献综述大赛 二等奖

    1.2024年联合国粮食及农业组织青年墙报挑战赛二等奖

  • 研究方向

    1.小分子化合物单细胞单克隆抗体制备


    2.牛病及宠物病毒单细胞同源抗体的制备


    3.牛病相关致病机理及调控研究

  • 科研项目

    国家自然科学青年基金项目(负责人,2023-2027)

    浙江省自然科学青年基金项目(负责人,2023-2026)

    国家博士后面上项目(负责人,2023-2025)

    浙江农林大学人才启动项目(负责人,2023-2026)

  • 发表论文

    SCI收录

    1. Peipei Li, Weilin Wu,Yuan Li, Zhihua Qin, Yingjie Zhang, Changfei Duan, Kai Wen, Xuezhi Yu, Jianzhong Shen, and Zhanhui Wang* Antibody Recognition Profile-Aided Hapten Design to Modulate Antibody Generation with Anticipated Performance for Immunoassay Development[J]. Analytical Chemistry, 2024, 96(50): 19869-19879.

    2.Yuan Li,Ling Yang, Wenbo Yu, Xuezhi Yu, Kai Wen, Bing Shao, Jiefang Sun, Jianzhong Shen, Zhanhui Wang*. Highly efficient and precise two-step cell selection method for tetramethylenedisulfotetramine-specific monoclonal antibody production. Journal of Hazardous Materials, 2022, 424: 127689.

    3.Yuan Li, Peipei Li, Yuebin Ke, Xuezhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen, and Zhanhui Wang*. Monoclonal Antibody Discovery Based on Precise Selection of Single Transgenic Hybridomas with an On-cell-surface and Antigen-specific Anchor. ACS Applied Materials & Interfaces.2022, 14(15): 17128-17141. (Cover paper)

    4.Yuan Li, Peipei Li, Yuebin Ke, Xuezhi Yu, Wenbo Yu, Kai Wen Jianzhong Shen, and Zhanhui Wang*. Rare Monoclonal Antibody Discovery Based on Indirect Competitive Screening of Single Hapten-specific Rabbit Antibody Secreting Cell. Analyst. 147(13): 2942-2952.(Cover paper)

    5.Yuan Li, Qing Yu, Wenbo Yu, Suxia Zhang, Jianzhong Shen, Zhanhui Wang, Xuezhi Yu*. Development of fluorescence polarization immunoassay with scFv to detect fumonisin Bs in maize and simultaneous study of their molecular recognition mechanism[J]. Frontiers in Chemistry, 2022, 10: 829038.

    6.Yuan Li, Yahui Wang, PeiPei Li, Yingjie Zhang, Yuebin Ke, Wenbo Yu, Kai Wen, Shuangyang Ding, Zhanhui Wang, and Xuezhi Yu*. High efficient chemiluminescent immunoassays for the detection of diclazuril in chicken muscle based on biotin–streptavidin system[J]. Food and Agricultural Immunology, 2020, 31(1): 255-267.

    7.Yuan Li, Yuan Li, Minggang Liu, Yihui Kong, Lina Guo, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Kai Wen, Zhanhui Wang*. Significantly improved detection performances of immunoassay for ractopamine in urine based on highly urea-tolerant rabbit monoclonal antibody[J]. Food and Chemical Toxicology, 2022, 168: 113358.

    8.Yuan Li, Yuan Li, Yihui Kong, Xuezhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang*. Characteristics of rabbit hapten-specific and germline-based BCR repertoires following repeated immunization[J]. One Health Advances, One Health Adv. 1, 17 (2023).

    9.Yuan Li,Yahui Wang, PeiPei Li, Yingjie Zhang, Yuebin K, Wenbo Yu, Kai Wen, Shuangyang Ding, Zhanhui Wang, and Xuezhi Yu. High efficient chemiluminescent immunoassays for the detection of diclazuril in chicken muscle based on biotin–streptavidin system[J]. Food and Agricultural Immunology, 2020, 31(1): 255-267.

    10. Peipei Li, Yuchen Bai, Haiyang Jiang, Yingjie Zhang,Yuan Li, Changfei Duan, Kai Wen, Xuezhi Yu, Zhanhui Wang*. Broad-specificity antibody profiled by hapten prediction and its application in immunoassay for fipronil and major metabolites[J]. Journal of Hazardous Materials, 2023, 441: 129931.

    11. Leina Dou, Yingjie Zhang, Yuchen Bai,Yuan Li, Minggang Liu, Shibei Shao, Qing Li, Wenbo Yu, Jianzhong Shen*, and Zhanhui Wang* (2022). Advances in chicken IgY-based immunoassays for the detection of chemical and biological hazards in food samples. Journal of Agricultural and Food Chemistry, 70(4): 976-991.

    12. Ling Yang, Xiya Zhang, Dongshuai Shen, Xuezhi Yu,Yuan Li, Kai Wen, Jianzhong Shen and Zhanhui Wang. Hapten design and monoclonal antibody to fluoroacetamide, a small and highly toxic chemical[J]. Biomolecules, 2020, 10(7): 986.

    13. Baolei Dong, Hongfang Li, Jiefang Sun,Yuan Li, Ghulam Mujtaba Mari, Xue zhi Yu, Wenbo Yu, Kai Wen, Jianzhong Shen, Zhanhui Wang. Magnetic assisted fluorescence immunoassay for sensitive chloramphenicol detection using carbon dots@ CaCO3 nanocomposites[J]. Journal of Hazardous Materials, 2021, 402: 123942.

    14. Xinlong Liang, Jiaying Zhou, Mengmeng Wang, Jing Wang, Houhui Song, Yigang Xu, andYuan Li*. Progress and prospect of polysaccharides as adjuvants in vaccine development. Virulence. 2024,15(1):2435373.

    15. Xin Yao, Linhan Zhong, Mengmeng Wang, Mei Wang, Yanyan Han, Yixin Wang, Jiaying Zhou, Jingge Song,Yuan Li*, Yigang Xu. Up-regulated lncRNA CYLD as a ceRNA of miR-2383 facilitates bovine viral diarrhea virus replication by promoting CYLD expression to counteract RIG-I-mediated type-I IFN production[J]. International Journal of Biological Macromolecules, 2023, 253: 12735

    16. Wenlu Fan, Yixin Wang, Shen Jiang,Yuan Li, Houhui Song*, Yigang Xu*. Identification of key proteins of cytopathic biotype bovine viral diarrhea virus involved in activating NF-κB pathway in BVDV-induced inflammatory response [J]. Virulence, 2022, 13(1): 1884-1899.

    17. Yingying Ma, Yanyan Han,Yuan Li, Wenlu Fan, Xin Yao, Xinning Huang, Mei Wang, Sheng Jiang, Jinghua Zhao, Xinyuan Qiao, Houhui Song, Yigang Xu. Augmentation of 3β-hydroxysteroid-Δ24 reductase (DHCR24) expression induced by bovine viral diarrhea virus infection facilitates viral replication via promoting cholesterol synthesis[J]. Journal of Virology, 2022, 96(24): e01492-2

    18. Huaming Xi, Wenjing Shan, Minghui Li, Ziqian Wang,Yuan Li. Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality[J]. Andrology, 2025, 13(4): 911-920.

    19.Yuan Li, Lishu Li, Wenjie Xiong, Xing Duan, Huaming Xi.Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells[J]. Theriogenology, 2024, 214: 192-200.

    20.Huaming Xi, Ziqian Wang, Minghui Li, Xing Duan, andYuan Li. Paeoniflorin promotes ovarian development in mice by activating mitophagy and preventing oxidative stress[J]. International Journal of Molecular Sciences, 2024, 25(15): 8355.

    21. Zhiwei Zhu, Yueyue Ma,Yuan Li,Zhixue Cheng, Huifeng Li, Lihuan Zhang, Dongmei Xu and Pengfei Li*. Comparison of miRNA-101a-3p and miRNA-144a-3p regulation with the key genes of alpaca melanocyte pigmentation. BMC Molecular Biol. 2019, 20 (1): 19.

    22. Zhiwei Zhu,Yuan Li, Wenyan Liu, Junping He, Lihuan Zhang, Huifeng Li, Pengfei Li, Lihua Lv. Comprehensive circRNA expression profile and construction of circRNA- associated ceRNA network in fur skin. Exp Dermatol. 2018, 27 (3): 251-257.

    23. Zhiwei Zhu, Yongqiang Cai,Yuan Li, Huifeng Li, Lihuan Zhang, Dongmei Xu, Xiuju Yu, Pengfei Li, Lihua Lv*. miR-148a-3p inhibits alpaca melanocyte pigmentation by targeting MITF. Small Ruminant Research. 177 (2019): 44-49.

    24. Zhiwei Zhu, Yueyue Ma,Yuan Li, Pengfei Li, Zhixue Cheng, Huifeng Li, Lihuan Zhang, Zhongwei Tang. The comprehensive detection of miRNA, lncRNA, and circRNA in regulation of mouse melanocyte and skin development. Biological Research.2020, 53:4.

  • 出版刊物

    1.“十四五”国家重点出版物规划项目——《中国兽药与研究应用全书》,参编

    2.浙江省普通本科高校“十四五”重点立项建设教材——《兽医微生物学实验教程》,参编

  • 授权专利

    4.沈建忠、王战辉、温凯、于雪芝、余文博、江海洋、李园、李培培。单个浆细胞的特异性筛选及单克隆抗体的制备技术。ZL 202011112963.8

    3.王战辉、沈建忠、温凯、余文博、于雪芝、江海洋、李园、李培培。单个抗原特异性转基因杂交瘤细胞筛选方法。ZL 202111306352.6

    2.王战辉、沈建忠、温凯、余文博、于雪芝、江海洋、李园、李培培。单个记忆B细胞的特异性筛选及单克隆抗体的制备。ZL 202011112975.5

    1.王战辉、沈建忠、温凯、余文博、于雪芝、江海洋、李培培、李园。氟苯尼考及氟苯尼考胺半抗原和人工抗原及其制备方法和应用。申请号:202111364657.2