浙江省杭州市临安区武肃街666号学2-305

邮编：311300

E-mail:zhufei@zafu.edu.cn

电话/传真：

1998.09－2002.07 大连海洋大学水产养殖农学学士

2002.09－2005.05 大连海洋大学水生生物理学硕士

2006.03－2009.03 浙江大学动物营养与饲料农学博士

2009.07－2011.06 浙江大学生物学博士后（优秀）

2011.09－2012.10 浙江农林大学动物科技学院专任教师，讲师

2012.11－2023.12 浙江农林大学动物科技学院·动物医学院专任教师，副研究员，期间2013年起任硕士研究生导师

2024.01－至今 浙江农林大学动物科技学院·动物医学院专任教师，教授

1.《水产动物疾病》本科生

2.《水产动物养殖》本科生

3.《动物传染病学》研究生

1.2020年获浙江农林大学“育人奖”先进个人

2.2019年获浙江农林大学研究生优秀导学团队

3.2019年指导研究生马雄超获浙江省专业学位优秀研究生实践成果

4.2018年指导研究生孙保贞获浙江省优秀硕士学位论文

5.2020年指导研究生钱希逸获国家奖学金

6.2016年指导研究生孙保贞获国家奖学金

7.2020年指导研究生赖勇勇获浙江农林大学第二届研究生博新学术交流论坛农林生物类一等奖

8.2021年指导研究生赖勇勇获浙江农林大学优秀专业硕士学位论文

9.2019年指导研究生马雄超获浙江农林大学优秀专业硕士学位论文

10.2017年指导研究生孙保贞获浙江农林大学优秀硕士毕业论文

主要从事经济甲壳动物的病害与免疫学研究，探索无脊椎动物病毒感染与宿主细胞分子免疫相互作用的机制，借助先进的分子和细胞生物学研究方法，挖掘还未被揭示的先天性免疫机理，同时以此为靶向来筛选一些提高先天性免疫力的分子制剂。同时从绿色养殖和环境保护的角度出发深入研究养殖环境污染物对甲壳动物的免疫毒理学。

主持的项目

1.国家自然科学基金面上项目―细胞吞噬相关miRNA在对虾抗白斑综合征病毒中的作用（31370050）

2.国家自然科学基金青年项目―小G蛋白（Rab、Ran）在对虾抗病毒细胞吞噬中的作用(31001127)

3.浙江省自然科学基金面上项目―microRNA-125/133在拟穴青蟹感染白斑综合征病毒免疫反应中的作用机制 (LY20C190001)

4.浙江省重点实验室开放项目―月桂酸单甘油酯和槲皮素保护红螯螯虾抗白斑综合征病毒感染的机制研究（L20210068）

5.企业横向项目―对虾白斑综合征病毒有效免疫蛋白的功效检测技术（H20180147）

6.浙江省教育厅项目―葡聚糖包被siRNA抗对虾白斑综合征病毒研究（Y200908288）

参与的项目

1.国家高技术研究发展计划（863计划）2011AA10A216-3对虾抗病毒靶向药物研发。

2.国家重点基础研究发展计划（973计划）2012CB114400-G“海水养殖动物主要病毒性疫病爆发机理与免疫防治的基础研究”

3.农业部公益性行业（农业）科研专项“养殖虾类病毒病快速诊断与生物防控技术的研究”研究课题。

1. Yunchao Zhang, Qi Wang, Fei Zhu*. Epigallocatechin-3-gallate attenuates the sulfamethoxazole-induced immunotoxicity and reduces SMZ residues in Procambarus clarkii. Journal of Hazardous Materials 2024, 472: 134602.

2. Fei Zhu. A review on the application of herbal medicines in the disease control of aquatic animals. Aquaculture 2020, 526: 735422. (2021 ESI高被引文章)

3. Chongyang Xiao, Yunfei Zhang, Fei Zhu*. Immunotoxicity of polychlorinated biphenyls (PCBs) to the marine crustacean species, Scylla paramamosain. Environmental Pollution 2021, 291: 118229.

4. Qi Wang, Xiujuan Zhou, Qingri Jin, Fei Zhu*. Effects of the aquatic pollutant sulfamethoxazole on the innate immunity and antioxidant capacity of the mud crab Scylla paramamosain. Chemosphere 2023, 349: 140775.

5. Xiujuan Zhou, Yongyong Lai, Fei Zhu*. The hematopoietic cytokine Astakine play a vital role in hemocyte proliferation and innate immunity in Scylla paramamosain. International Journal of Biological Macromolecules 2023, 224: 396-406.

6. Yunfei Zhang, Yongyong Lai, Xiujuan Zhou, Fei Zhu*. The Role of microRNA-133 in Hemocyte Proliferation and Innate Immunity of Scylla paramamosain. Frontiers in Immunology 2022, 12: 812717.

7. Xiyi Qian, Yunfei Zhang, Xiujuan Zhou, Fei Zhu*. MicroRNA-125 modulates hemocyte proliferation through regulating Astakine expression and participate the disease resistant in Scylla paramamosain. Aquaculture 2024, 582: 740491

8. Yongyong Lai, Yinglei Xu, Fei Zhu*. Effects of Janus kinase (JAK) on hemocyte proliferation and disease resistance in Scylla paramamosain. Aquaculture 2022, 555:738209

9. Chongyang Xiao, Yunfei Zhang, Fei Zhu*. Effect of dietary sodium butyrate on the innate immune response of Procambarus clarkii and disease resistance against white spot syndrome virus. Aquaculture 2021, 541: 736784.

10. Wenxin Jin, Yongyong Lai, Fei Zhu*. Effect of dietary fucoidan on innate immune response of Procambarus clarkii and disease resistance against white spot syndrome virus. Aquaculture 2021, 534: 736233.

11. Jing Gong, Xiaoyi Pan, Xiujuan Zhou, Fei Zhu*. Dietary glycerol monolaurate protects Cherax quadricarinatus against white spot syndrome virus infection. Fish Shellfish Immunology 2022, 131:1085-1091.

12. Xiyi Qian, Fei Zhu*. Use of glycerol monolaurate as a treatment against white spot syndrome virus in crayfish (Procambarus clarkii). Aquaculture 2021, 541: 736853.

13. Yongyong Lai, Ming Luo, Fei Zhu*. Dietary Bacillus amyloliquefaciens enhance survival of white spot syndrome virus infected crayfish. Fish Shellfish Immunology 2020, 102: 161-168.

14. Xinyue Jiang, Wenxin Jin, Fei Zhu*. Dietary Hizikia fusiforme enhance survival of white spot syndrome virus infected crayfish Procambarus clarkii. Fish Shellfish Immunology 2020, 103: 88-94.

15. Qingri Jin, Guangyan Tian, Jun Wu, Hulin Jiang, Fei Zhu*. Identification and characterization of hemocyte microRNAs in mud crab Scylla paramamosain in response to Vibrio parahemolyticus infection. Aquaculture 2020, 524: 735288.

16. Qian Xiyi, Lai Yongyong, Zhu Fei*. Molecular characterization of carboxypeptidase B-like (CPB) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunology 2019, 94: 434-446.

17. Qian Xiyi, Zhu Fei*. Hesperetin protects crayfish Procambarus clarkii against white spot syndrome virus infection. Fish Shellfish Immunology 2019, 93: 116-123.

18. Ma Xiongchao, Zhu Fei*, Jin Qinri. Antibiotics and chemical disease-control agents reduce innate disease resistance in crayfish. Fish Shellfish Immunology 2019, 86: 169-178.

19. Zhu Fei*, Qian Xiyi, Ma Xiongchao. Comparative transcriptomic analysis of crab hemocytes in response to white spot syndrome virus or Vibrio alginolyticus infection. Fish Shellfish Immunology 2018, 80: 165-179.

20. Yuebo Zhao, Kaini Zheng, Fei Zhu*. Molecular characterization of troponin C (TnC) in Scylla paramamosain and its role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunology 2020, 98: 522-533.

21. Sun Baozhen, Qian Xiyi, Zhu Fei*. Molecular characterization of shrimp harbinger transposase derived 1 (HARBI1)-like and its role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunology 2018, 78: 222-232.

22. Baozhen Sun, Zhi Wang, Ziyan Wang, Xiongchao Ma, Zhu Fei*. A proteomic study of hemocyte proteins from mud crab (Scylla paramamosain) infected with white spot syndrome virus (WSSV) or Vibrio alginolyticus. Frontiers in Immunology, 2017, 8: 468.

23. Wang Zhi, Sun Baozhen, Zhu Fei*. Molecular characterization of glutaminyl-peptide cyclotransferase (QPCT) in Scylla paramamosain and its role in Vibrio alginolyticus and white spot syndrome virus (WSSV) infection. Fish Shellfish Immunology 2018, 78: 299-309.

24. Ziyan Wang, Baozhen Sun, Zhu Fei*. Molecular characterization of diphthamide biosynthesis protein 7 in Marsupenaeus japonicus and its role in white spot syndrome virus infection. Fish Shellfish Immunology 2018, 75: 8-16.

25. Xiongchao Ma, Baozhen Sun, Zhu Fei*. Molecular cloning of Kuruma shrimp Marsupenaeus japonicus endonuclease-reverse transcriptase and its positive role in white spot syndrome virus and Vibrio alginolyticus infection. Fish Shellfish Immunology 2018, 73: 297-308.

26. Zhi Wang, Baozhen Sun, Zhu Fei*. The shrimp hormone receptor acts as an anti-apoptosis and anti-inflammatory factor in innate immunity. Fish Shellfish Immunology 2017, 72: 581-592.

27. Wang Zhi, Zhu Fei*. MicroRNA-100 is involved in shrimp immune response to white spot syndrome virus (WSSV) and Vibrio alginolyticus infection. Scientific Reports, 2017, 7: 42334.

28. Baozhen Sun, Zhi Wang, Zhu Fei*. The crustin-like peptide plays opposite role in shrimp immune response to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection. Fish Shellfish Immunology 2017, 66: 487-496.

29. Wang Zhi, Zhu Fei*. Different roles of a novel shrimp microRNA in white spot syndrome virus (WSSV) and Vibrio alginolyticus infection. Developmental Comparative Immunology 2017, 79: 21-30.

30. Sun Baozhen, Zhi Wang, Zhu Fei*. Molecular cloning of kuruma shrimp Marsupenaeus japonicus phosphopyruvate hydratase and its role in infection by white spot syndrome virus and Vibrio alginolyticus. Aquaculture 2016, 455: 87-96.