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程昌勇

博士/教授/副院长

程昌勇,教授,博士生导师,动物科技学院·动物医学院副院长,兽医公共卫生教工党支部书记。国家重点研发计划青年科学家项目和浙江省杰出青年基金项目获得者,入选浙江省“高校领军人才培养计划”青年优秀人才、浙江省高校“院士结对培养青年英才计划”等,长期致力于重要人兽共患胞内病原菌环境适应和感染免疫机制以及病原宿主互作机制等领域的基础和应用研究。主持国家重点研发计划青年科学家项目、国家自然科学基金、浙江省杰出青年基金等各类科研项目;获浙江省科技进步二等奖1项、浙江省青年科技工作者优秀论文等,在Advanced Science、JBC、Gut Microbes等国内外期刊发表学术论文100余篇,制定标准8项,担任国际学术期刊专题主编。


  • 通讯地址

    浙江省杭州市临安区武肃街666号

    邮编:311300

  • 教育背景

    2009/09-2014/06: 博士(硕博连读),浙江大学动物科学学院,预防兽医学专业


    2005/09-2009/06: 本科,安徽科技学院动物科学学院,动物医学专业

  • 工作经历

    2021/06至今:浙江农林大学 动科动医学院,副院长(分管科研和学科学位点建设)


    2014/07至今:浙江农林大学 动科动医学院,讲师、副教授、教授


    2018/01-2021/07:浙江农林大学 动科动医学院,兽医学学科/学位点建设负责人


    2019/09-2020/09:加州大学伯克利分校,分子与细胞生物学系,国家公派访问学者

  • 学术兼职

    1. 2021/09至今:担任Frontiers in Immunology期刊Guest Editor


    2. 2020/12至今:担任Frontiers in Cellular and Infection Microbiology期刊Guest Editor


    3. 2020/12至今:担任Frontiers in Veterinary Science期刊Associate Editor


    4. 2020/11至今:担任浙江省畜牧兽医学会第十七届理事会理事


    5. 2021/10至今:浙江省免疫学会动物免疫与疫病防控专业委员会委员


    6. 2018/05至今:担任浙江省畜牧兽医学会兽医公共卫生与畜产品安全分会副秘书长


    7. 2023/11至今:担任中国畜牧兽医学会兽医食品卫生学分会第七届理事会理事

  • 课程教学

    1. 动物检疫检验学(本科生)

    2. 兽医公共卫生学(本科生和研究生)

  • 研究方向

    1. 食源性病原微生物污染防控和兽医公共卫生


    2. 重要人兽共患胞内菌感染免疫及与宿主互作


    3. 基于减毒李斯特菌递呈载体的肿瘤免疫治疗

  • 科研项目

    【主持部分科研项目】


    9. 国家重点研发计划青年科学家项目(项目负责人)


    8. 国家自然科学基金面上项目(项目负责人)


    7. 浙江省重点研发计划专项(课题负责人)


    6. 国家自然科学基金面上项目(项目负责人)


    5. 国家重点研发计划专项(子课题负责人)


    4. 浙江省自然科学基金一般项目(项目负责人)


    3. 杭州市农业与社会发展科研主动设计项目(课题负责人)


    2. 国家自然科学基金青年基金项目(项目负责人)


    1. 浙江省公益技术研究农业项目(项目负责人)

  • 发表论文

    SCI收录(按日期排序)

    43.Xia, J., Jiang,G., Luo,Y., Wang,Z., Li,J., Fu,Z., Qin,Q., Xu, J., Deng, S., Chen, M., Han, Y, Jiang, L., Song, H., Cheng, C*. (2025). "Beyond antimicrobial resistance: MATE-type efflux pump FepA contributes to flagella formation and virulence in Listeria monocytogenes." Appl Environ Microbiol. doi: 10.1128/aem.00462-25.

    42.Guan, H., Wu, H., Gan, M., Zhang, J., Wang, J., Liu, S., Chen, S., Jiao, Y., Li, F., Huang, S., Lin, S., Chen, H., Feng, Y., Cheng, C., Song, H., Wang, C., Zheng, L., Fu, J., and Ouyang, S. (2025). "Contact-dependent antagonism is mediated by a T7SSb toxin effector-immunity protein pair via ADP-ribosylation." Science Bulletin. Doi: 10.1016/j.scib.2025.03.025.

    41.Wu, Q., Lin, G., Li, J., Zhu, B., Lei, C., Zhou, Z., Fu, Y., Lei, L., Xu, J., Xia, J., Jiang, L., Song, H.*, and Cheng, C*. (2025). "RAA-CRISPR/Cas13a-assisted lateral flow strip for Feline herpesvirus Type I point-of-care testing." Microchem J, 211: p. 113135.

    40.Sun, J., Wang, J., Jiang, X., Xia, J., Han, Y., Chen, M., Xu, J., Deng, S., Cheng, C.*, and Song, H*. (2024). "LADS: a powerful vaccine platform for cancer immunotherapy and prevention." BMC Biol, 22(1): p. 291.

    39. Cheng, C., Chen, M., Sun, J., Xu, J., Deng, S., Xia, J., Han, Y., Zhang, X., Wang, J., Lei, L., Zhai, R., Wu, Q., Fang, W., and Song, H.* (2024). "The MICOS complex subunit Mic60 is hijacked by intracellular bacteria to manipulate mitochondrial dynamics and promote bacterial pathogenicity. " Advanced Science. p. e2406760.

    38. Deng, S., Li, H., Zhou, C., Fan, J., Zhu, F., Jin, G., Xu, J., Xia, J., Wang, J., Nie, Z., Zhou, R., Song, H.*, and Cheng, C.* (2024). "Streptococcus suis 5'-nucleotidases contribute to adenosine-mediated immune evasion and virulence in a mouse model." Virulence, 20240916, 15(1): 2401963.

    37. Cheng, C., Jiang, L., Li, X., Song, H., and Fang,W.*(2024). “Can natural preservatives serve as a new line of protective technology against bacterial pathogens in meat and meat products?” Food Quality and Safety. 2024, 8, 1–17.

    36. Wang, J., Cui, M., Liu, Y., Chen, M., Xu, J., Xia, J., Sun, J., Jiang, L., Fang, W., Song, H.*, and  Cheng, C.* (2024). “The mitochondrial carboxylase PCCA interacts with Listeria monocytogenes phospholipase PlcB to modulate bacterial survival”Appl Environ Microbiol. p. e0213523.


    35. Deng, S., Liao, J., Li, H., Xu, J., Fan, J., Xia, J., Wang, J., Lei, L., Chen, M., Han, Y., Zhai, R., Zhou, C., Zhou, R.,Cheng, C.*, and Song, H.* (2024). "Streptococcus suis subtilisin-like serine proteases SspA-1 and SspA-2 interplay with complement C3a and C5a to facilitate bacterial immune evasion and infection."Virulence: p. 2301246.



    34. Xia, J., Luo, Y., Chen, M., Liu, Y., Wang, Z., Deng, S., Xu, J., Han, Y., Sun, J., Jiang, L., Song, H.*, andCheng, C. *(2023). "Characterization of a DsbA family protein reveals its crucial role in oxidative stress tolerance of Listeria monocytogenes."Microbiol Spectr: p. e0306023.



    33. Chen, M., Ren, G., Zhang, X., Yang, L., Ding, Q., Sun, J., Xia, J., Xu, J., Jiang, L., Fang, W.,Cheng, C.*, and Song, H.* (2023). "DegU-mediated suppression of carbohydrate uptake in Listeria monocytogenes increases adaptation to oxidative stress."Appl Environ Microbiol: p. e0101723.



    32. Wang, J., He, Z., Cui, M., Sun, J., Jiang, L., Zhuang, N., Zhu, F., Zhang, X., Song, H.*, andCheng, C*.(2023). "Hypoxia-induced HIF-1alpha promotes Listeria monocytogenes invasion into tilapia."Microbiol Spectr: p. e0140523.



    31. Chen, M., Zhang, J., Xia, J., Sun, J., Zhang, X., Xu, J., Deng, S., Han, Y., Jiang, L., Song, H.*, andCheng, C.*(2023). "Listeria monocytogenes GshF contributes to oxidative stress tolerance via regulation of the phosphoenolpyruvate-carbohydrate phosphotransferase system."Microbiol Spectr: p. e0236523.



    30. Han, Y., Luo, P., Zeng, H., Wang, P., Xu, J., Chen, P., Chen, X., Chen, Y., Cao, Q., Zhai, R., Xia, J., Deng, S., Cheng, A.,Cheng, C.*, and Song, H. (2023). "The effect of O-antigen length determinant wzz on the immunogenicity of Salmonella Typhimurium for Escherichia coli O2 O-polysaccharides delivery."Vet Res, 54(1): 15.



    29.Cheng C, Liu F, Jin H, Xu X, Xu J, Deng S, Xia J, Han Y, Lei L, Zhang X and Song H* (2021) The DegU Orphan Response Regulator Contributes to Heat Stress Resistance in Listeria monocytogenes.Front. Cell. Infect. Microbiol.11:761335. doi: 10.3389/fcimb.2021.761335.



    28. Wang P, Jia Y, Han Y, Wang W, Zhu Y, Xu J, Guan C, Ying J, Deng S, Wang J, Zhang X, Chen M,Cheng C*(Co-Corr. Author)and Song H* (2021) Eimeria acervulina Microneme Protein 3 Inhibits Apoptosis of the Chicken Duodenal Epithelial Cell by Targeting the Casitas B-Lineage Lymphoma Protein.Front. Vet. Sci.8:636809. doi: 10.3389/fvets.2021.636809



    27. Han, Y., Luo, P., Chen, Y., Xu, J., Sun, J., Guan, C., Wang, P., Chen, M., Zhang, X., Zhu, Y., Zhu, T., Zhai, R.,Cheng, C.*(Co-Corr. Author)and Song, H.* (2021). "Regulated delayed attenuation improves vaccine efficacy in preventing infection from avian pathogenic Escherichia coli O78 and Salmonella Typhimurium."Veterinary Microbiology254 (2021): 109012.



    26.Cheng, C., Han, X., Xu, J., Sun, J., Li, K., Han, Y., Chen, M., and Song, H.* (2021).YjbH mediates the oxidative stress response and infection by regulating SpxA1 and the phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) in Listeria monocytogenes.Gut Microbes13(1): 1-19.



    25. Wang, P., Zhao, H., Wang, Q., Gao, C., Wu, H.,Cheng, C.* (Co-Corr. Author)and Song, H.* (2020). "Identification of host protein CBL interacting with Eimeria acervulina microneme protein MIC3."Acta Biochim Biophys Sin: pii: 5879271. doi: 10.1093/abbs/gmaa086.



    24.Cheng, C., Sun, J., Yu, H., Ma, T., Guan, C., Zeng, H., Zhang, X., Chen, Z., Song, H. (2020). Listeriolysin O pore-forming activity is required for ERK1/2 phosphorylation during Listeria monocytogenes infection.Front. Immunol.doi: 10.3389/fimmu.2020.01146.



    23. Zhang, X., Guan, C., Hang, Y., Liu, F., Sun, J., Yu, H., Gan, L., Zeng, H., Zhu, Y., Chen, Z., Song, H., andCheng, C.*(2020). "An M29 Aminopeptidase from Listeria Monocytogenes Contributes to In Vitro Bacterial Growth but not to Intracellular Infection."Microorganisms, 8(1).



    22. Sun, J., Hang, Y., Han, Y., Zhang, X., Gan, L., Cai, C., Chen, Z., Yang, Y., Song, Q., Shao, C., Yang, Y., Zhou, Y., Wang, X.,Cheng, C.* (Co-Corr. Author)and Song, H.* (2019). "Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes."Virulence10(1): 910-924.


    21.Cheng, C., Wang H., Ma T., Han X., Yang Y., Sun J., Chen Z., Yu H., Hang Y., Liu F., Fang W., Jiang L., Cai C. and Song H. (2018). "Flagellar Basal Body Structural Proteins FlhB, FliM, and FliY Are Required for Flagellar-Associated Protein Expression in Listeria monocytogenes."Front Microbiol9: 208.


    20.Cheng, C., Jiang L., Ma T., Wang H., Han X., Sun J., Yang Y., Chen Z., Yu H., Hang Y., Liu F., Wang B., Fang W., Huang H., Fang C., Cai C., Freitag N. and Song H. (2017). "Carboxyl-Terminal Residues N478 and V479 Required for the Cytolytic Activity of Listeriolysin O Play a Critical Role in Listeria monocytogenes Pathogenicity."Front Immunol8: 1439.


    19.Cheng, C., Dong Z., Han X., Wang H., Jiang L., Sun J., Yang Y., Ma T., Shao C., Wang X., Chen Z., Fang W., Freitag N. E., Huang H. and Song H. (2017). "Thioredoxin A Is Essential for Motility and Contributes to Host Infection of Listeria monocytogenes via Redox Interactions."Front Cell Infect Microbiol7: 287.


    18.Cheng, C., Dong Z., Han X., Sun J., Wang H., Jiang L., Yang Y., Ma T., Chen Z., Yu J., Fang W. and Song H. (2017). "Listeria monocytogenes 10403S arginine repressor ArgR finely tunes arginine metabolism regulation under acidic conditions."Front Microbiol8: 145.


    17.Cheng, C., Yang Y., Dong Z., Wang X., Fang C., Yang M., Sun J., Xiao L., Fang W. and Song H. (2015). "Listeria monocytogenes varies among strains to maintain intracellular pH homeostasis under stresses by different acids as analyzed by a high-throughput microplate-based fluorometry."Front Microbiol6: 15.


    16.Cheng, C., Wang X., Dong Z., Shao C., Yang Y., Fang W., Fang C., Wang H., Yang M., Jiang L., Zhou X. and Song H. (2015). "Aminopeptidase T of M29 Family Acts as A Novel Intracellular Virulence Factor for Listeria monocytogenes Infection."Sci Rep5: 17370.


    15.Cheng, C., Chen J., Fang C., Xia Y., Shan Y., Liu Y., Wen G., Song H. and Fang W. (2013). "Listeria monocytogenes aguA1, but not aguA2, encodes a functional agmatine deiminase: biochemical characterization of its catalytic properties and roles in acid tolerance."J Biol Chem288(37): 26606-26615.


    14.Cheng, C., Chen J., Shan Y., Fang C., Liu Y., Xia Y., Song H. and Fang W. (2013). "Listeria monocytogenes ArcA contributes to acid tolerance."J Med Microbiol62(Pt 6): 813-821.


    13. Fang, C., Cao T., Shan Y., Xia Y., Xin Y.,Cheng, C., Song H., Bowman J., Li X., Zhou X. and Fang W. (2016). "Comparative Genomic Analysis Reveals That the 20K and 38K Prophages in Listeria monocytogenes Serovar 4a Strains Lm850658 and M7 Contribute to Genetic Diversity but Not to Virulence." J Microbiol Biotechnol 26(1): 197-206.


    12. Fang, C., Shan Y., Cao T., Xia Y., Xin Y.,Cheng, C., Song H., Li X. and Fang W. (2016). "Prevalence and Virulence Characterization of Listeria monocytogenes in Chilled Pork in Zhejiang Province, China." Foodborne Pathog Dis 13(1): 8-12.


    11. Hu, Q., Wu M., Fang C.,Cheng, C., Zhao M., Fang W., Chu P. K., Ping Y. and Tang G. (2015). "Engineering Nanoparticle-Coated Bacteria as Oral DNA Vaccines for Cancer Immunotherapy." Nano Letters 15(4): 2732-2739.


    10. Shan, Y., Fang C.,Cheng, C., Wang Y., Peng J. and Fang W. (2015). "Immersion infection of germ-free zebrafish with Listeria monocytogenes induces transient expression of innate immune response genes." Front Microbiol 6: 373.


    9. Fang, C., Cao T.,Cheng, C., Xia Y., Shan Y., Xin Y., Guo N., Li X., Song H. and Fang W. (2015). "Activation of PrfA results in overexpression of virulence factors but does not rescue the pathogenicity of Listeria monocytogenes M7." J Med Microbiol 64(8): 818-827.


    8. Wen, G., Zhang Y., Zhang X., Hu H., Zhang H.,Cheng, C., Wang X., Li X. and Fang W. (2013). "Functional characterization of porcine LSm14A in IFN-beta induction." Vet Immunol Immunopathol 155(1-2): 110-116.


    7. Chen, J., Fang C., Zhu N., Lv Y.,Cheng, C., Bei Y., Zheng T. and Fang W. (2012). "Genetic organization of ascB-dapE internalin cluster serves as a potential marker for Listeria monocytogenes sublineages IIA, IIB, and IIC." J Microbiol Biotechnol 22(5): 575-584.


    6. Chen, J.,Cheng, C., Lv Y. and Fang W. (2013). "Genetic diversity of internalin genes in the ascB-dapE locus among Listeria monocytogenes lineages III and IV strains." J Basic Microbiol 53(9): 778-784.


    5. Zhao, H., Chen J., Fang C., Xia Y.,Cheng, C., Jiang L. and Fang W. (2011). "Deciphering the biodiversity of Listeria monocytogenes lineage III strains by polyphasic approaches." J Microbiol 49(5): 759-767.


    4. Jiang, J., Chen J.,Cheng, C., Hu H., Bai F., Chen N., Yan G. and Fang W. (2011). "Disruption of InlC2 enhances the internalization of Listeria monocytogenes by epithelial cells." World Journal of Microbiology and Biotechnology 27(9): 2155-2161.


    3. Chen, J., Xia Y.,Cheng, C., Fang C., Shan Y., Jin G. and Fang W. (2011). "Genome sequence of the nonpathogenic Listeria monocytogenes serovar 4a strain M7." J Bacteriol 193(18): 5019-5020.


    2. Chen, J.,Cheng, C., Xia Y., Zhao H., Fang C., Shan Y., Wu B. and Fang W. (2011). "Lmo0036, an ornithine and putrescine carbamoyltransferase in Listeria monocytogenes, participates in arginine deiminase and agmatine deiminase pathways and mediates acid tolerance." Microbiology 157(Pt 11): 3150-3161.


    1. Chen, J., Chen Q., Jiang L.,Cheng, C., Bai F., Wang J., Mo F. and Fang W. (2010). "Internalin profiling and multilocus sequence typing suggest four Listeria innocua subgroups with different evolutionary distances from Listeria monocytogenes." BMC Microbiol 10: 97.

  • 教材编写

    1.《动物检疫检验学》(第二版),科学出版社,副主编;
    2.《兽医微生物学精要(双语版)》,科学出版社,副主编