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当前位置: 首页 >> 师资队伍 >> 副教授

何珂

博士/副教授

动物科技学院教师,主要从事鸟类免疫基因进化方向研究。获得国家自然科学基金青年项目、浙江省自然基金青年项目、浙江省教育厅科学基金等多个项目,参与国家科技部科技基础性工作专项、多项国家自然科学基金面上项目、浙江省十三五育种重大专项和多项地方合作项目。发表十多篇SCI论文。

  • 通讯地址

    浙江省杭州市临安区武肃街666号学2-416

    邮编:311300

    E-mail:heke@zafu.edu.cn

    电话/传真:

  • 教育背景

    博士(2007/09-2012/06): 浙江大学生命科学学院,生态所,动物学专业


    学士(2003/09-2007/06): 浙江大学生命科学学院,生物技术系

  • 工作经历

    2012/07 - 至今:浙江农林大学动物科技学院 教师


    2016/6 -2019/1:浙江大学动科院,在职博士后


    2018/11 -2019/11:美国威斯康星大学,访问学者

  • 课程教学

    1.动物生物学(本科)


    2.动物行为学(本科)

  • 研究方向

    1.鸟类免疫基因进化


    2.挖掘野生鸭类资源应用于育种

  • 科研项目

    1.基于MHC基因的不同习性斑嘴鸭种群的适应性进化研究。国家自然科学青年基金项目(31600292,20.0万元,2016-2019)


    2.华东黄山-天目山脉及仙霞岭-武夷山脉生物多样性调查,科技部基础性工作专项子课题(2015FY110200第八课题组,2015-2020,45万)


    3. 剑门关土鸡高效绿色养殖技术集成与推广,浙江省尖兵领雁-地方合作项目(2022C04014,40万元,2021-2024)

  • 发表论文

    2022年


    1. He K#, Liang CH, Zhu Y, Dunn P, Zhao AY, and Minias P#. (2022). Reconstructing Macroevolutionary Patterns in Avian MHC Architecture With Genomic Data. Frontiers in Genetics 13.


    2021年


    2.Qin S, Dunn PO, Yang Y, Liu H, He K#. Polymorphism and varying selection within the MHC class I of four Anas species. Immunogenetics. 2021 Oct;73(5):395-404. doi: 10.1007/s00251-021-01222-9.


    3.He K#, Minias P, Dunn PO#. Long-Read Genome Assemblies Reveal Extraordinary Variation in the Number and Structure of MHC Loci in Birds. Genome Biol Evol. 2021 Feb 3;13(2):evaa270. doi: 10.1093/gbe/evaa270.


    4.Wang H*, He K*, Zeng X, Zhou X, Yan F, Yang S, Zhao AY#. Isolation and identification of goose skeletal muscle satellite cells and preliminary study on the function of C1q and tumor necrosis factor-related protein 3 gene. Anim Biosci. 2021 Jun;34(6):1078-1087. doi: 10.5713/ajas.20.0430.


    5. Minias P#, He K, Dunn PO. The strength of selection is consistent across both domains of the MHC class I peptide-binding groove in birds. BMC Ecol Evol. 2021 May 8;21(1):80. doi: 10.1186/s12862-021-01812-x.


    6. Liu HY, He K, Ge YF, Wan QH, Fang SG#. Cape Feather Coloration Signals Different Genotypes of the Most Polymorphic MHC Locus in Male Golden Pheasants (Chrysolophus pictus). Animals (Basel). 2021 Jan 22;11(2):276. doi: 10.3390/ani11020276.


    2020年之前


    7.He K, Xin YP, Shan Y, Zhang X, Song HH, Fang WH#. Phosphorylation residue T175 in RsbR protein is required for efficient induction of sigma B factor and survival of Listeria monocytogenes under acidic stress. J Zhejiang Univ Sci B. 2019 Aug.;20(8):660-669. doi: 10.1631/jzus.B1800551.


    8. He K, Liu HY, Ge YF, Wu SY, Wan QH#. Historical gene flow and profound spatial genetic structure among golden pheasant populations suggested by multi-locus analysis. Mol Phylogenet Evol. 2017 May; 110:93-103. doi: 10.1016/j.ympev.2017.03.009.


    9. He K, Ren T, Zhu S, Liang S, Zhao A#. Transiently expressed pattern during myogenesis and candidate miRNAs of Tmem8C in goose. J Genet. 2017 Mar;96(1):39-46. doi: 10.1007/s12041-016-0737-8.


    10. Yu J*, He K*, Ren T, Lou Y, Zhao A#. High-throughput sequencing reveals differential expression of miRNAs in prehierarchal follicles of laying and brooding geese. Physiol Genomics. 2016 Jul 1;48(7):455-63. doi: 10.1152/physiolgenomics.00011.2016.


    11. He K, Ren T, Zhu S, Zhao A#. The complete mitochondrial genome of Fulica atra (Avian, Gruiformes, Rallidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016 Sep;27(5):3161-2. doi: 10.3109/19401736.2015.1007315.


    12. Ren T, Liang S, Zhao A#, He K#. Analysis of the complete mitochondrial genome of the Zhedong White goose and characterization of NUMTs: Reveal domestication history of goose in China and Euro. Gene. 2016 Feb 10;577(1):75-81. doi: 10.1016/j.gene.2015.11.018.


    13. Zeng QQ*, He K*, Sun DD, Ma MY, Ge YF, Fang SG, Wan QH#. Balancing selection and recombination as evolutionary forces caused population genetic variations in golden pheasant MHC class I genes. BMC Evol Biol. 2016 Feb 18;16:42. doi: 10.1186/s12862-016-0609-0.


    14. Zeng QQ, Zhong GH, He K, Sun DD, Wan QH. Molecular characterization of classical and nonclassical MHC class I genes from the golden pheasant (Chrysolophus pictus). Int J Immunogenet. 2016 Feb;43(1):8-17. doi: 10.1111/iji.12245.


    15. He K*, Ye Q*, Zhu Y*, Chen H, Wan QH, Fang SG#. A bacterial artificial chromosome library for the Chinese alligator (Alligator sinensis). Gene. 2012 Oct 1;507(1):74-8. doi: 10.1016/j.gene.2012.06.035.


    16. Ye Q*, He K*, Wu SY, Wan QH#. Isolation of a 97-kb minimal essential MHC B locus from a new reverse-4D BAC library of the golden pheasant. PLoS One. 2012;7(3):e32154. doi: 10.1371/journal.pone.0032154.


    17. He K, Zhang P, Fang S G, Wan QH#. Development and characterization of 14 novel microsatellite markers from the golden pheasant (Chrysolophus pictus). Conservation Genetics, 2009, 10(3):511-513.


    中文期刊


    1.何叶艳, 吕凯伦, 董加俊,俞一钒,何珂#. 梅花鹿华南亚种和东北亚种警戒声比较[J]. 四川动物, 2019, 38(3):8.


    2.曾雪花, 高旭龙, 王吟方亭,刘玉清,赵阿勇,何珂#. 黑熊皮肤横梗霉菌株的分离和鉴定[J]. 野生动物学报, 2018, 39(3):5.


    3.何珂,程昌勇,方春,宋厚辉,方维焕#.单核细胞增生李斯特菌抗酸应激机制[J]. 微生物学通报, 2017, 44(12):9.