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当前位置: 首页 >> 师资队伍 >> 教授

许成钢

博士/教授

许成钢,博士,教授,博士生导师。中科院青年创新促进会会员,山西省高等学校优秀青年学术带头人,山西省优秀青年基金获得者,三晋英才。主要从事畜禽肠道和自然环境厌氧梭菌的功能基因组学和分子遗传学研究。目前在Nature Communications、Bioresource Technology、Biotechnology for Biofuels、ACSSynthetic Biology、Applied Microbiology and Biotechnology等杂志发表30余篇学术论文,授权专利3项。主持国家自然科学基金项目4项,浙江省自然科学基金重点项目1项,山西省自然科学基金优秀青年项目1项,并参与多项国家重点研发计划和国家科技支撑计划课题。

  • 通讯地址

    浙江省杭州市临安区武肃街666号浙江农林大学东湖校区学2-302-2办公室

    邮编:311300

    E-mail:xucg@zafu.edu.cn

    电话/传真:

  • 教育背景

    博士(2003/09-2008/06): 山西大学生物技术研究所,生物化学与分子生物学专业


    学士(1999/09-2003/06): 山西大学生命科学学院,生物技术专业

  • 工作经历

    2022/07 - 至今:浙江农林大学动物科技学院 教授


    2017/02 - 2022/06:山西大学生物技术研究所教授


    2008/07 - 2017/01:中国科学院青岛生物能源与过程研究所 助理研究员、副研究员、项目研究员

  • 学术兼职

    中国生物化学与分子生物学会生物技术专业分会委员

  • 课程教学

    动物生物化学

  • 获奖荣誉

    山西省高等学校优秀青年学术带头人(2019)

    三晋英才(2018)

    中科院青年创新促进会会员(2016)

  • 研究方向

    1.梭菌RNA剪切与转录后调控


    2.畜禽致病梭菌的致病和耐药机制


    3.益生梭菌的合成生物学改造和应用


    4.畜禽污染物资源化利用

  • 科研项目

    1.转录后水平控制细菌蛋白复合体化学计量比的机制研究-以ATP合成酶为例. 浙江省自然科学基金重点项目(Z24C010001, 2024.01-2026.12)


    2.高效降解木质纤维素的人工纤维小体的分子设计与自组装. 浙江农林大学林学领域标志性论文培育项目(202360002205, 2023.07-2024.12)


    3.浙江农林大学科研发展基金项目. (2022LFR065,2022.08-2027.08)


    4.SpyTag/SpyCatcher介导人工纤维小体的分子设计与自组装.国家自然科学基金面上项目(32170053, 2022.1-2025.12)


    5.高效降解利用酒糟微生物的筛选. 山西大学杏花村学院开发课题(XCSXU-KF-202021, 2021.1-2021.12)


    6.纤维小体骨架蛋白的分子设计及其与酶亚基协同效应研究. 山西省应用基础研究计划优秀青年基金项目(201901D211195, 2019.09-2022.09)


    7.sRNA作为核糖开关调控纤维小体表达的分子机制. 国家自然科学基金面上项目(31871252, 2019.01-2022.12)


    8.选择性RNA剪切和保护调控纤维小体化学计量的分子机制研究. 国家自然科学基金面上项目(31571282, 2016.01-2019.12)


    9.碳代谢抑制作用调控纤维小体表达的分子机制研究. 国家自然科学基金青年基金项目(31200029, 2013.01-2015.12)


    10.细菌酶复合体纤维素降解转化机理和纤维小体的解析、重构. 国家重点基础研究发展计划项目子课题(2011CB707404, 2013.01-2015.08)


    11.纤维素高温整合生物加工生产液体燃料. 国家科技支撑计划子课题(2011BAD22B02-01, 2011.01-2013.12)

  • 发表论文

    2026

    1.Liu Y, Pan Y, Liu Na, Yan Z, Ye L, Bayer E, Song H*,Xu C*. Design and assembly of extended artificial cellulosomes mediated by covalent self-assembly systems.Chemical Engineering Journal. 2026, 529:12464.

    2.Wang D, Wang N, Song H*,Xu C*.Precise control of transcriptional stoichiometry in bacteria: From mechanisms to synthetic biology applications.Biotechnology Advances. 2026, 86: 108748.

    2025

    1.Ren Z, Qiu Z, Tian Y, You M,Xu C*.Identification and regulation of an alternative PTS system for disaccharide utilization inClostridium acetobutylicum.Applied and Environmental Microbiology. 2025, 91(11): e00709-25.

    2.Liu Z, Tang Y, He M, Zhao Q,Xu C*. Molecular drivers of fusion plasmid: mechanistic insights and evolutionary implications.Journal of Antimicrobial Chemotherapy. 2025, dkaf309.

    3.Liu Z, He M, Zhao Q, Tang Y,Xu C*. Comparative genomic analysis ofParaclostridium bifermentansin the intestinal microbiome of Hu sheep.Veterinary Research Communications. 2025, 49(5):276.

    4.Wang D, Pan Y, Ye L, Zhao Q, Liu Z, Qiao M*, Song H*,Xu C*.Aprogrammable DNA cleavage nuclease from mesophilic bacteriaClostridium beijerinckii.International Journal of Biological Macromolecules.2025, 316:144692.

    5.Zhang W, Qiu Z, Zhao Q, Liu Z, Zhang X, Song H*,Xu C*.Expression of xylanase XynB is synergistically controlled by two two-component systems inRuminiclostridium cellulolyticum.Applied and Environmental Microbiology.2025,91(6):e00062-25.

    6.You M, Ren Z, Ye L, Zhao Q, Liu Z, Song H*,Xu C*.Combining transcriptomic and metabolomic insights into carbohydrate utilization byRuminiclostridium papyrosolvensDSM2782.Biotechnology for Biofuels and Bioproducts. 2025, 18:22.

    2024

    1.Shen Z, Pan Y, Liu Y, Song H*,Xu C*.Construction of Chitinase Complexes Using Self-Assembly Systems for Efficient Hydrolysis of Chitin.ACS Synthetic Biology.2024, 13(12):4143-4153.

    2.Liu Z, Zhao Q,Xu C*, Song H*. Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost.Ecology and Evolution. 2024, 14:e70121.

    3.Wang D, Liu N, Qiao M,Xu C*. Gallic acid as biofilm inhibitor can improve transformation efficiency ofRuminiclostridium papyrosolvens.Biotechnology Letters. 2024, 46(6):1143-1153

    2023

    1.Wang D, You M, Qiu Z, Li P, Qiao M,Xu C*.Development of an efficient ClosTron system for gene disruption inRuminiclostridium papyrosolvens.Applied Microbiology and Biotechnology. 2023, 107:1801-1812.

    2.Wang N, Li P, Cheng Y, Song H*,Xu C*.Stem-loop structures control mRNA processing of the cellulosomalcip‑celoperon inRuminiclostridium cellulolyticum.Biotechnology for Biofuels and Bioproducts. 2023, 16:106.

    3.You M, Zhao Q, Liu Y, Zhang W, Shen Z, Ren Z*,Xu C*. Insights into lignocellulose degradation: comparative genomics of anaerobic and cellulolyticRuminiclostridiumtype species.Frontiers in Microbiology. 2023, 14:1288286.

    2022

    1.Cheng Y, Wang N, Ren Z,Xu C*. Development of fluorescence-based nucleic acid blot hybridization method using Cy5.5 labeled DNA probes.Journal of Microbiological Methods. 2022, 197:106479.

    2.Wu S, You M, Wang N, Ren Z,Xu C*.Internal transcription terminators control stoichiometry of ABC transporters in cellulolytic clostridia.Microbiology Spectrum. 2022, 10(2):e01656-21.

    3.Wang N, Yan Z, Liu N, Zhang X,Xu C*. Synergy of Cellulase Systems betweenAcetivibrio thermocellusandThermoclostridium stercorariumin Consolidated-Bioprocessing for Cellulosic Ethanol.Microorganisms. 2022, 10(3):502.

    4.Cheng Y, Jiang Y, Ren Z, Fu Y,Xu C*.Development of an in vivo methylation system for transformation ofRuminiclostridium cellulolyticum.Journal of Applied Microbiology. 2022, 132(3): 1926-1935.

    5.Wang C, Jia Q, Guo X, Li K, Chen W, Shen Q,Xu C, Fu Y. microRNA-34 family: From mechanism to potential applications.International Journal of Biochemistry and Cell Biology. 2022, 144:106168.

    Selected to represent

    1.Jiang Y, Fu Y, Ren Z, Gou H,Xu C*. Screening and application of inducible promoters inRuminiclostridium papyrosolvens.Letters in Applied Microbiology. 2020, 71(4):428-436.

    2.Ren Z, You W, Wu S, Poetsch A*,Xu C*.Secretomic analyses ofRuminiclostridium papyrosolvensreveal its enzymatic basis for lignocellulose degradation.Biotechnology for Biofuels. 2019, 12:183.

    3.Zou X, Ren Z, Wang N, Cheng Y, Jiang Y, Wang Y,Xu C*.Function analysis of 5'-UTR of the cellulosomalxyl-doc cluster inClostridium papyrosolvens.Biotechnology for Biofuels. 2018, 11:43.

    4.Teng L, Wang K, Xu J,Xu C*. Flavin mononucleotide (FMN)-based fluorescent protein (FbFP) as reporter for promoter screening inClostridium cellulolyticum.Journal of Microbiological Methods. 2015, 119:37-43.3.

    5.Xu C, Huang R, Teng L, Jing X, Hu J, Cui G, Wang Y, Cui Q, Xu J.Cellulosome stoichiometrty inClostridium cellulolyticumis regulated by selective RNA processing and stabilization.Nature Communications. 2015, 6:6900.

    6.Xu C, Huang R, Teng L, Wang D, Hemme CL, Borovok I, He Q, Lamed R, Bayer EA, Zhou J, Xu J.Structure and regulation of the cellulose degradome inClostridium cellulolyticum.Biotechnology for Biofuels. 2013, 6:73.

    7.Xu C, Qin Y, Li Y, Ji Y, Song H, Xu J.Factors influencing cellulosome activity in Consolidated-Bioprocessing of cellulosic ethanol.Bioresource Technology. 2010, 101(24): 9560-9569.

    8.Xu C, Fan X, Fu Y, Liang A. Effect of location of the His-tag on the production of soluble and functional Buthusmartensii Karsch insect toxin.Protein Expression and Purification. 2008, 59(1):103-9.

  • 出版刊物

    《非粮生物质炼制技术-木质纤维素生物降解机理及其酶系合成调控》化学工业出版社,2017年1月,ISBN:9787122274526(参编)

  • 授权专利

    1.许成钢, 滕琳, 徐健. 一种厌氧梭菌组成型高效表达启动子及其应用.发明专利号: ZL201510621010.1.


    2.许成钢, 滕琳, 徐健. 一种厌氧梭菌木聚糖诱导型启动子及其应用.发明专利号: ZL201510621152.8.


    3.许成钢, 王艺霖, 滕琳, 徐健. 一种原核细胞转录后水平控制不同基因表达比例的方法.发明专利号: ZL201610833323.8.